Card 12 / 33: You are evaluating a 29 year old physician for constipation. Her physical examination including ano-rectal exam is normal. Thyroid testing and serum calcium levels are normal. A colonoscopy is normal. You make a diagnosis of constipation-predominant irritable bowel syndrome. The patient has minimal response to bulk forming agents and osmotic laxatives. You recommend beginning tegaserod. The patient asks how this drug works. Which of the following is the best description of the mechanism of action of tegaserod?
A)
It stimulates 5-HT3 receptors
B)
It stimulates nitric oxide containing neurons
C)
It inhibits acetylcholine containing neurons
D)
It inhibits water absorption in the colon
E)
It stimulates 5-HT4 receptors
Answer:
E) It stimulates 5-HT4 receptors
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Gastrointestinal Pathophysiology Exam 2006
Author:
Dr.Tamsin KnoxProfessor
Tufts University School of Medicine
USA
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