Question 11 / 30:  You are evaluating a 29 year old physician for constipation. Her physical examination

including ano-rectal exam is normal. Thyroid testing and serum calcium levels are

normal. A colonoscopy is normal. You make a diagnosis of constipation-predominant

irritable bowel syndrome. The patient has minimal response to bulk forming agents and

osmotic laxatives. You recommend beginning tegaserod. The patient asks how this drug

works.

Which of the following is the best description of the mechanism of action of tegaserod?

A  It stimulates 5-HT3 receptors
B  It stimulates nitric oxide containing neurons
C  It inhibits acetylcholine containing neurons
D  It inhibits water absorption in the colon
E  It stimulates 5-HT4 receptors
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Gastrointestinal Pathophysiology Exam 2006

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Attribution:  Laurence Scott Bailen, Tamsin Knox, Paul Abourjaily, Fredric D. Gordon,Marshall Kaplan,Andrew G. Plaut. PPY 222 Gastrointestinal Pathophysiology, Spring 2007. (Tufts University OpenCourseWare), http://ocw.tufts.edu/Course/47 (Accessed 3 May, 2014). License: Creative Commons BY-NC-SA
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