Card 3 / 30: A 42 year old man abuses intravenous drugs. He complains of 2 weeks of anorexia and nausea. He noted that his urine turned dark and his stool turned light. Blood work is consistent with acute viral hepatitis. Serologic studies are done: Hepatitis A IgG: positive Hepatitis A IgM: negative Hepatitis C Antibody: negative Hepatitis B surface antigen: positive Hepatitis B surface antibody: negative Hepatitis B core IgM antibody: positive Which of the following best explains the mechanism of hepatic injury in this patient?
A)
Direct viral cytotoxic effect
B)
Immune mediated hepatocyte damage
C)
Direct inhibition of hepatocyte DNA replication
D)
Direct inhibition of hepatocyte mRNA translation
E)
Antibody destruction of virus
Answer:
B) Immune mediated hepatocyte damage
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Gastrointestinal Pathophysiology Exam 2005
Author:
Dr.Laurence BailenProfessor
Tufts University School of Medicine
USA
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