Question 2 / 27:  A 42 year old man abuses intravenous drugs. He complains of 2 weeks of anorexia and nausea.

He noted that his urine turned dark and his stool turned light.

Blood work is consistent with acute viral hepatitis. Serologic studies are done:

Hepatitis A IgG: positive

Hepatitis A IgM: negative

Hepatitis C Antibody: negative

Hepatitis B surface antigen: positive

Hepatitis B surface antibody: negative

Hepatitis B core IgM antibody: positive

Which of the following best explains the mechanism of hepatic injury in this patient?

A  Direct viral cytotoxic effect
B  Immune mediated hepatocyte damage
C  Direct inhibition of hepatocyte DNA replication
D  Direct inhibition of hepatocyte mRNA translation
E  Antibody destruction of virus
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Gastrointestinal Pathophysiology Exam 2005

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Attribution:  Laurence Scott Bailen, Tamsin Knox, Paul Abourjaily, Fredric D. Gordon,Marshall Kaplan,Andrew G. Plaut. PPY 222 Gastrointestinal Pathophysiology, Spring 2007. (Tufts University OpenCourseWare), http://ocw.tufts.edu/Course/47 (Accessed 3 May, 2014). License: Creative Commons BY-NC-SA
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