Canine dysautonomia is a rare condition Brooke Delaney Clin Sci I

Question 12 / 30: Canine dysautonomia is a rare condition in dogs associated with degeneration of autonomic nervous system. What is the best way to diagnose this disease?

A Run a myasthenia gravis antibody titer test

B Fecal exam and urinalysis since these dogs have diarrhea and dysuria

C Barium contrast study radiograph

D Schmirmer tear test and pharmacologic testing of the pupils (i.e. provocative ocular test using
Pilocarpine) to determine mydriasis

E Run a thyroid panel

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Explanation:

Dilute pilocarpine (0.05% ophthalmic solution) results in rapid pupillary constriction in dogs with dysautonomia because of supersensitivity of the denervated muscle to cholinergic drugs. The prognosis is grave.

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