A 45 year-old male came to you for consult Clinical Issues in TB

Question 9 / 10: A 45 year-old male came to you for consult due to a 3-week history of cough and progressive weight loss. Work-up revealed tuberculosis. He mentioned that he was also diagnosed with cirrhosis after consulting with his gastroenterologist a week ago and that all tests were normal. In starting anti-TB meds, which will you avoid?

A None. I will start the usual 4-drug regimen

B I will have to avoid at least 2 of the most hepatotoxic drugs

C I will not start a regimen with any hepatotoxic drug as he re mainsat risk for drug-induced
liver injury

D I will avoid pyrazinamide as this is the most hepatotoxic among the anti-TB drugs

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Clinical Issues in TB Management

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Cath Yu

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