Card 18 / 24: Strychnine (gopher bait) causes arched back and neck (opisthotonos) and convulsions. What is the mechanism of action?
A)
uncoupled oxidative phosphorylation
B)
inhibits GABA receptors
C)
inhibits Na+ influx and K+ efflux
D)
inhibits acetylcholinesterase (AchE)
E)
inhibits glycine on anterior horn of spinal cord and endogenous transmitter release at Renshaw cells.
Answer:
E) inhibits glycine on anterior horn of spinal cord and endogenous transmitter release at Renshaw cells.
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