Card 21 / 30: An endoscopy performed on a 58 year old woman on ibuprofen for arthritis reveals a large ulcer in the antrum of the stomach. There are no endoscopic stigmata of bleeding. A biopsy is obtained from the stomach for rapid urease testing and this is negative. Which of the following best explains the pathogenesis of this ulcer?
A) Reduced blood supply to the stomach
B) H pylori infection
C) Excessive gastric acid production
D) Excessive gastrin production
E) Inhibition of prostaglandin synthesis

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