• Card 16 / 34: A 32 year-old man has Crohn’s disease involving the ileum and colon. When he was first diagnosed he had ocular discomfort and was diagnosed with uveitis. Several years later he developed back pain due to sacroileitis and a rash consistent with pyoderma gangrenosum. He has had intermittent bouts of right knee inflammation consistent with arthritis. Recently, abnormal liver function tests were noted and a diagnosis of primary sclerosing cholangitis is being entertained. Of the all the extraintestinal manifestations of Crohn’s disease, which of the following will most likely be related to the activity of the intestinal disease?
    1.) Sacroileitis
    2.) Peripheral arthritis
    3.) Uveitis
    4.) Primary sclerosing cholangitis
    5.) Pyoderma gangrenosum

    Answer:
    2.) Peripheral arthritis

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Explanation:

Peripheral arthritis. The other complications are less likely to follow the course of the intestinal disease.

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Gastrointestinal Pathophysiology Self-Assessment

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Attribution:  Laurence Scott Bailen, Tamsin Knox, Paul Abourjaily, Fredric D. Gordon,Marshall Kaplan,Andrew G. Plaut. PPY 222 Gastrointestinal Pathophysiology, Spring 2007. (Tufts University OpenCourseWare), http://ocw.tufts.edu/Course/47 (Accessed 3 May, 2014). License: Creative Commons BY-NC-SA
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