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    The same second messengers are used in many different cells, but the response to second messengers is different in each cell. How is this possible?

    Different cells produce different proteins, including cell-surface receptors and signaling pathway components. Therefore, they respond to different ligands, and the second messengers activate different pathways. Signal integration can also change the end result of signaling.

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Source:  OpenStax, Open genetics. OpenStax CNX. Jan 08, 2015 Download for free at https://legacy.cnx.org/content/col11744/1.3
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