What is the mechanism of action of Fipronil Brooke Delaney Pesticides

Question 9 / 20: What is the mechanism of action of Fipronil (Frontline)?

A Fipronil inhibits the oxidation of NADH to NAD+ which leads to an energy deficiency in cells.

B Fipronil binds to the membrane lipid phase near the Na+ channel.

C Fipronil inhibits Na+ influx and K efflux

D Fipronil noncompetitively binds GABA receptors and blocks Cl- influx

E Fipronil is an AchE inhibitor

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Explanation:

Poison occurs in dogs an cats due to ingestion/licking of Frontline product. Clincal signs are tremors, convulsions and death. Frontline cannot be used on rabbits.

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Brooke Delaney

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