9.2 Eukaryotic cells  (Page 6/5)

Introduction

The cell, too, has a geography. And its reactions occur in a colloidal apparatus, of which the form, and the catalytic activity of its manifold surfaces, must efficiently contribute to the due guidance of chemical reactions.

Have you ever heard the phrase “form follows function?” It’s a philosophy practiced in many industries. In architecture, this means that buildings should be constructed to support the activities that will be carried out inside them. For example, a skyscraper should be built with several elevator banks; a hospital should be built so that its emergency room is easily accessible.

Our natural world also utilizes the principle of form following function, especially in cell biology, and this will become clear as we explore eukaryotic cells ( [link] ). Unlike prokaryotic cells, eukaryotic cells have: 1) a membrane-bound nucleus; 2) numerous membrane-bound organelles such as the endoplasmic reticulum, Golgi apparatus, chloroplasts, mitochondria, and others; and 3) several, rod-shaped chromosomes. Of these, Hopkins points out the membrane systems (the "manifold surfaces") as being especially important. Indeed, the study of eukaryotic cells is in many respects the study of the structure and function of these surfaces. Different organelles have different forms and functions based on the form and function of their component membranes. Indeed, the word “organelle” means “little organ,” and organelles have specialized shapes and specialized functions, just as the organs of your body have specialized shapes and functions.

At this point, it should be clear to you that eukaryotic cells have a more complex structure than prokaryotic cells. Organelles allow different functions to be compartmentalized in different areas of the cell. Before turning to organelles, let’s first examine two important components of the cell: the plasma membrane and the cytoplasm.

The plasma membrane

Like prokaryotes, eukaryotic cells have a plasma membrane ( [link] ), a phospholipid bilayer with embedded proteins that separates the internal contents of the cell from its surrounding environment. A phospholipid is a lipid molecule with two fatty acid chains and a phosphate-containing group. The plasma membrane controls the passage of organic molecules, ions, water, and oxygen into and out of the cell. Wastes (such as carbon dioxide and ammonia) also leave the cell by passing through the plasma membrane. Thus, the plasma membrane is said to be semi-permeable

The plasma membranes of cells that specialize in absorption are folded into fingerlike projections called microvilli (singular = microvillus); ( [link] ). Such cells are typically found lining the small intestine, the organ that absorbs nutrients from digested food. This is an excellent example of form following function. People with celiac disease have an immune response to gluten, which is a protein found in wheat, barley, and rye. The immune response damages microvilli, and thus, afflicted individuals cannot absorb nutrients. This leads to malnutrition, cramping, and diarrhea. Patients suffering from celiac disease must follow a gluten-free diet.