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Card 17 / 40:
What cell cycle events will be affected in a cell that produces mutated (non-functional) cohesin protein?
If cohesin is not functional, chromosomes are not packaged after DNA replication in the S phase of interphase. It is likely that the proteins of the centromeric region, such as the kinetochore, would not form. Even if the mitotic spindle fibers could attach to the chromatids without packing, the chromosomes would not be sorted or separated during mitosis.
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