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The body contains a large variety of ions, or electrolytes, which perform a variety of functions. Some ions assist in the transmission of electrical impulses along cell membranes in neurons and muscles. Other ions help to stabilize protein structures in enzymes. Still others aid in releasing hormones from endocrine glands. All of the ions in plasma contribute to the osmotic balance that controls the movement of water between cells and their environment.
Electrolytes in living systems include sodium, potassium, chloride, bicarbonate, calcium, phosphate, magnesium, copper, zinc, iron, manganese, molybdenum, copper, and chromium. In terms of body functioning, six electrolytes are most important: sodium, potassium, chloride, bicarbonate, calcium, and phosphate.
These six ions aid in nerve excitability, endocrine secretion, membrane permeability, buffering body fluids, and controlling the movement of fluids between compartments. These ions enter the body through the digestive tract. More than 90 percent of the calcium and phosphate that enters the body is incorporated into bones and teeth, with bone serving as a mineral reserve for these ions. In the event that calcium and phosphate are needed for other functions, bone tissue can be broken down to supply the blood and other tissues with these minerals. Phosphate is a normal constituent of nucleic acids; hence, blood levels of phosphate will increase whenever nucleic acids are broken down.
Excretion of ions occurs mainly through the kidneys, with lesser amounts lost in sweat and in feces. Excessive sweating may cause a significant loss, especially of sodium and chloride. Severe vomiting or diarrhea will cause a loss of chloride and bicarbonate ions. Adjustments in respiratory and renal functions allow the body to regulate the levels of these ions in the ECF.
[link] lists the reference values for blood plasma, cerebrospinal fluid (CSF), and urine for the six ions addressed in this section. In a clinical setting, sodium, potassium, and chloride are typically analyzed in a routine urine sample. In contrast, calcium and phosphate analysis requires a collection of urine across a 24-hour period, because the output of these ions can vary considerably over the course of a day. Urine values reflect the rates of excretion of these ions. Bicarbonate is the one ion that is not normally excreted in urine; instead, it is conserved by the kidneys for use in the body’s buffering systems.
| Electrolyte and Ion Reference Values | ||||
|---|---|---|---|---|
| Name | Chemical symbol | Plasma | CSF | Urine |
| Sodium | Na + | 136.00–146.00 (mM) | 138.00–150.00 (mM) | 40.00–220.00 (mM) |
| Potassium | K + | 3.50–5.00 (mM) | 0.35–3.5 (mM) | 25.00–125.00 (mM) |
| Chloride | Cl - | 98.00–107.00 (mM) | 118.00–132.00 (mM) | 110.00–250.00 (mM) |
| Bicarbonate | HCO 3 - | 22.00–29.00 (mM) | ------ | ------ |
| Calcium | Ca ++ | 2.15–2.55 (mmol/day) | ------ | Up to 7.49 (mmol/day) |
| Phosphate | 0.81–1.45 (mmol/day) | ------ | 12.90–42.00 (mmol/day) |
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