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Card 5 / 8:
Explain the difference between a proto-oncogene and a tumor suppressor gene.
A proto-oncogene is the segment of DNA that codes for one of the positive cell-cycle regulators. If that gene becomes mutated to a form that is overactive, it is considered an oncogene. A tumor suppressor gene is a segment of DNA that codes for one of the negative cell-cycle regulators. If that gene becomes mutated to a form that is underactive, the cell cycle will run unchecked.
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