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    If a series of genetic mutations prevented some, but not all, of the complement proteins from binding antibodies or pathogens, would the entire complement system be compromised?

    The entire complement system would probably be affected even when only a few members were mutated such that they could no longer bind. Because the complement involves the binding of activated proteins in a specific sequence, when one or more proteins in the sequence is absent, the subsequent proteins would be incapable of binding to elicit the complement’s pathogen-destructive effects.

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Source:  OpenStax, University of georgia biology. OpenStax CNX. Dec 09, 2013 Download for free at https://legacy.cnx.org/content/col11585/1.6
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