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    What is the major mechanism that results in acclimatization?

    A major mechanism involved in acclimatization is the increased production of erythrocytes. A drop in tissue levels of oxygen stimulates the kidneys to produce the hormone erythropoietin, which signals the bone marrow to produce erythrocytes. As a result, individuals exposed to a high altitude for long periods of time have a greater number of circulating erythrocytes than do individuals at lower altitudes.

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Source:  OpenStax, Anatomy & Physiology: energy, maintenance and environmental exchange. OpenStax CNX. Aug 21, 2014 Download for free at https://legacy.cnx.org/content/col11701/1.1
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