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Peripheral blood film from a 10-year-old Brazilian boy with Romaña’s sign– painless, unilateral, palpebral edema withconjunctivitis and swelling of regional lymph nodes.
Shown between red blood cells is a trypomastigote of Trypanosoma cruzi. This form of the parasite is visible in the blood only during the acute stage of the disease and is diagnostic.Romaña’s sign, which often heralds the acute phase, develops when the vector, a reduviid bug, deposits the parasite on or near the conjunctiva.
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