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Card 10 / 21: Myelofibrosis is a disorder in which inflammation and scar tissue formation in the bone marrow impair hemopoiesis. One sign is an enlarged spleen. Why?
Answer:
When disease impairs the ability of the bone marrow to participate in hemopoiesis, extramedullary hemopoiesis begins in the patient's liver and spleen. This causes the spleen to enlarge.
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Attribution:
OpenStax College. Anatomy & Physiology, OpenStax-CNX Web site. http://cnx.org/content/col11496/1.6/, Jun 11, 2014
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