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In contrast to communicable infectious diseases, a noncommunicable infectious disease is not spread from one person to another. One example is tetanus , caused by Clostridium tetani , a bacterium that produces endospores that can survive in the soil for many years. This disease is typically only transmitted through contact with a skin wound; it cannot be passed from an infected person to another person. Similarly, Legionnaires disease is caused by Legionella pneumophila , a bacterium that lives within amoebae in moist locations like water-cooling towers. An individual may contract Legionnaires disease via contact with the contaminated water, but once infected, the individual cannot pass the pathogen to other individuals.

In addition to the wide variety of noncommunicable infectious diseases, noninfectious disease s (those not caused by pathogens) are an important cause of morbidity and mortality worldwide. Noninfectious diseases can be caused by a wide variety factors, including genetics, the environment, or immune system dysfunction, to name a few. For example, sickle cell anemia is an inherited disease caused by a genetic mutation that can be passed from parent to offspring ( [link] ). Other types of noninfectious diseases are listed in [link] .

Types of Noninfectious Diseases
Type Definition Example
Inherited A genetic disease Sickle cell anemia
Congenital Disease that is present at or before birth Down syndrome
Degenerative Progressive, irreversible loss of function Parkinson disease (affecting central nervous system)
Nutritional deficiency Impaired body function due to lack of nutrients Scurvy (vitamin C deficiency)
Endocrine Disease involving malfunction of glands that release hormones to regulate body functions Hypothyroidism – thyroid does not produce enough thyroid hormone, which is important for metabolism
Neoplastic Abnormal growth (benign or malignant) Some forms of cancer
Idiopathic Disease for which the cause is unknown Idiopathic juxtafoveal retinal telangiectasia (dilated, twisted blood vessels in the retina of the eye)
a) A micrograph showing round red blood cells (erythrocytes) and a darker oval cell (Plasmodium falciparum).b) A micrograph showing round red blood cells and a “C” shaped red blood cell labeled “sickle cell”.
Blood smears showing two diseases of the blood. (a) Malaria is an infectious, zoonotic disease caused by the protozoan pathogen Plasmodium falciparum (shown here) and several other species of the genus Plasmodium . It is transmitted by mosquitoes to humans. (b) Sickle cell disease is a noninfectious genetic disorder that results in abnormally shaped red blood cells, which can stick together and obstruct the flow of blood through the circulatory system. It is not caused by a pathogen, but rather a genetic mutation. (credit a: modification of work by Centers for Disease Control and Prevention; credit b: modification of work by Ed Uthman)
  • Describe how a disease can be infectious but not contagious.
  • Explain the difference between iatrogenic disease and nosocomial disease.

Periods of disease

The five periods of disease (sometimes referred to as stages or phases) include the incubation, prodromal, illness, decline, and convalescence periods ( [link] ). The incubation period occurs in an acute disease after the initial entry of the pathogen into the host (patient). It is during this time the pathogen begins multiplying in the host. However, there are insufficient numbers of pathogen particles (cells or viruses) present to cause signs and symptoms of disease. Incubation periods can vary from a day or two in acute disease to months or years in chronic disease, depending upon the pathogen. Factors involved in determining the length of the incubation period are diverse, and can include strength of the pathogen, strength of the host immune defenses, site of infection, type of infection, and the size infectious dose received. During this incubation period, the patient is unaware that a disease is beginning to develop.

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Source:  OpenStax, Microbiology. OpenStax CNX. Nov 01, 2016 Download for free at http://cnx.org/content/col12087/1.4
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