Director of Cell Therapy, In Vitro Pharmacology

Initial Therapeutics Inc
US - Massachusetts - Boston
January 18, 2025

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About the role:

At Takeda, we are a forward-looking, world-class R&D organization that unlocks innovation and delivers transformative therapies to patients.
By focusing R&D efforts on four therapeutic areas and other targeted investments, we push the boundaries of what is possible in order to bring life-changing therapies to patients worldwide.
Join Takeda as a Director of Cell Therapy where you will lead a team responsible for designing and implementing in vitro pharmacological assays, using state-of-the-art technologies and methodologies, leading the discovery of novel Cell Therapy products, and contributing to the strategic direction of our Cell Therapy research programs.
As part of the Vitro Pharmacology team, you will report to the Head of the team and be a highly skilled and experienced leader.
How you will contribute:

Strategic Leadership:
Provide strategic direction and leadership for the Cell Therapy in vitro pharmacology team, ensuring alignment with company goals and objectives.
Develop and implement innovative strategies to support the discovery and development of novel therapies.
Functional Leadership:
Lead the design, development, optimization, and execution of high-quality in vitro pharmacology assays to evaluate the activity, mechanism of action, and efficacy of Cell Therapy products.
Use cutting-edge technologies and methodologies to assess immune cell function and tumor-immune interactions.
Develop and implement strategies to enhance the in vitro pharmacology capabilities and throughput.
Stay up to date with the latest scientific advancements and industry trends.
Program Leadership:
Lead the Cell Therapy discovery programs with cross-functional teams, driving the programs from lead ID to preclinical development.
Candidates Screening and Profiling:
Oversee the screening and profiling of Cell Therapy candidates in relevant in vitro models including immune cell-based assays, co-culture systems, and 3D organoid models.
Evaluate candidate efficacy, potency and selectivity, to support lead optimization and candidate selection.
Mechanism of Action Studies:
Investigate the molecular mechanisms underlying the activity of Cell Therapy candidates using in vitro pharmacology approaches.
Cross-functional Collaboration:
Collaborate closely with interdisciplinary discovery teams in a matrix format, including biologics engineering, biologics production, analytics, translational scientists, and preclinical development teams to advance discovery programs.
Communicate results effectively and contribute to project team meetings, scientific discussions, and project planning activities.
Mentoring:
Mentor and develop junior scientists, fostering a culture of innovation, collaboration, and scientific excellence.
Minimum Requirements/Qualifications:

PhD degree in immunology, cancer biology, or a related field with 10+ years experience, or MS with 16+ years experience, or BS with 18+ years experience.
Minimum of 10 years of experience in Cell Therapy research, with a focus on immune cell biology, and tumor-immune interactions.
Minimum of 7 years of management experience.
Expertise in drug discovery and development processes, including hit identification, lead optimization, candidate selection, and preclinical development.
Proven track record of leading successful in vitro pharmacology efforts in the field of Cell Therapy, including assay development and validation, candidate screening, and mechanism of action studies.
Strong technical proficiency in a wide range of in vitro pharmacology techniques and assay formats.
Excellent leadership, communication, and interpersonal skills, with the ability to lead a team and projects and collaborate effectively across disciplines, demonstrate enterprise leadership with an ability to influence without authority.
Knowledge of regulatory requirements and guidelines for drug discovery and development.
More about us:

At Takeda, we are transforming patient care through the development of novel specialty pharmaceuticals and best in class patient support programs.
Takeda is a patient-focused company that will inspire and empower you to grow through life-changing work.
Certified as a Global Top Employer, Takeda offers stimulating careers, encourages innovation, and strives for excellence in everything we do.
We foster an inclusive, collaborative workplace, in which our teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world.
Locations:
Boston, MA
Worker Type:
Employee
Worker Sub-Type:
Regular
Time Type:
Full time
Job Exempt:
Yes
•

Read the full job description and apply online on the recuiter's web-site

Director of Cell Therapy, In Vitro Pharmacology

Director of Cell Therapy, In Vitro Pharmacology

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