Computational Biologist - Single Cell Genomics Team

Location:

Office in Barcelona [Spain].

Date of Publication:

01/01/2025

About Us:

The Centro Nacional de Análisis Genómico (CNAG) is one of the largest Genome Sequencing Centers in Europe.

The CNAG Consortium aims to carry out large-scale projects in DNA/RNA analysis for the improvement of quality of life in collaboration with the Spanish, European and International Research Community. CNAG researchers participate in major International Genome Initiatives such as the Human Cell Atlas (HCA), the International Cancer Genome Consortium (ICGC), the International Human Epigenome Consortium (IHEC), the International Rare Diseases Research Consortium (IRDiRC), the European Reference Genome Atlas (ERGA) and the European Infrastructure for life-science information (ELIXIR), as well as in several EU-funded projects.

The Role

We are hiring a 2 Computational Biologist to lead projects in immuno-oncology and inflammatory diseases. We aim to delineate mechanisms of immune cell infiltration and plasticity in tumors and inflamed tissues to provide an accurate patient prognosis and a precise prediction of therapy success. We are looking for enthusiastic computational scientists, motivated to improve our understanding of immune cell function in tumors/tissues. Together, we aim to bring single-cell and spatial genomics applications into clinical use and to advance pathology assessment with high-dimensional genomics readouts (next-generation pathology).

The candidate will be integrated in the Single Cell Genomics Team , a highly collaborative, international work environment with well-experienced colleagues in single-cell and spatial data generation and analysis. The projects the candidates will be involved in aim to understand the molecular and cellular basis of immunomodulating drug action through the application of multi-omics single-cell and spatial technologies on clinical samples.

Your tasks include the analysis of multi-modal single-cell and spatial data and the development of statistical methods to integrate multi-omics, spatial and clinical patient information. We are looking for highly motivated and a creative thinking individual who is interested in working in an environment where the technical sophistication of single-cell and spatial technologies meets innovative approaches for interpreting data and generating new knowledge. We require the ability for working in a multi-disciplinary team on collaborative projects.

✍️ Main tasks and responsibilities

Analyze multi-modal single-cell and spatial genomic data to identify mechanisms of immune cell infiltration and plasticity in tumors and inflamed tissues.
Develop and apply statistical methods to integrate multi-omics, spatial, and clinical patient data.
Innovate and refine computational techniques for single-cell and spatial data analysis.
Create tools and pipelines to enhance the integration of diverse data types, including genomic, transcriptomic, proteomic, and clinical datasets.
Work closely with a multi-disciplinary team, including biologists, clinicians, and other computational scientists, to design and execute research projects.
Contribute to research projects aimed at understanding the molecular and cellular basis of immunomodulating drug actions.
Provide guidance and mentorship to junior team members and other researchers in computational biology techniques and best practices.
Collaborate with clinical teams to bring single-cell and spatial genomics applications into clinical use.

Whom would we like to hire?

You have completed a PhD in Bioinformatics, Mathematics, Statistics or similar.
You are competent in Python or R.
You have excellent knowledge of Computational Biology.
Experience in single-cell and/or spatial analysis.

The Offer

Contract duration: 3 years.
Estimated annual gross salary: Salary is commensurate with qualifications and consistent with our pay scales.
Target start date: February - March 2025

✅ Benefits

Highly stimulating environment with state-of-the-art infrastructures, and unique Professional Career Plan and development opportunities.

We offer and promote a diverse and inclusive environment and welcomes applicants regardless of age, disability, gender, nationality, race, religion or sexual orientation, in a collaborative and supportive environment.

We are committed to reconcile a work and family life for our employees and are offering the opportunity to benefit from annual leave, full health and dental Insurance, flexible schedule, and the possibility of remote work.

We look forward to receiving your application and discovering how you can contribute to CNAG's success!

How to Apply:

All applications must include:

A complete CV including contact details.
Contact details of two referees.
A short motivation letter addressed to Dr Holger Heyn.

All applications must be addressed to Dr. Holger Heyn - *** / CC: ***

Deadline: Please submit your application by 31/01/2025.

See the CNAG Career site at our website: /cnag.eu/jobs
• sequencing for a better life