E1365%School VI of Medicine and Health Sciences, Department of Human Medicine, organization unit of PaediatricsOrt29.10.2024Befristetfor 3 yearsThe School VI of Medicine and Health Sciences comprises the fields of human medicine, medical physics and acoustics, neurosciences, psychology and health services research.
Together with the four regional hospitals, School VI forms the University Medicine Oldenburg.
Furthermore, the university cooperates closely with the University Medicine of the University of Groningen.Our overarching aim is to improve neurodevelopmental outcomes of preterm infants suffering from postnatal brain injury such as intraventricular hemorrhage.
Our objectives are:
To establish a developmental profile of CNS barrier-forming organoids/assembloids and to characterize how this recapitulates aspects of human cerebroventricular development;To profile proteomics, miRNA and EV content of organoid-derived CSF and how this is affected by prevalent postnatal insults;To develop pharmacological interventions targeting astrogliosis/pro-inflammatory pathways that might impact on developmental outcomes in preterm infants with postnatal brain injury.The project is a collaboration between the Perinatal Neurobiology Group and the Institute of Anatomy at the University of Oldenburg (Germany), and the Regenerative Medicine Laboratories at the University of Bristol.
The applicant will be based at Oldenburg but will also be offered the opportunity to undertake part of this work at the University of Bristol.The PhD project will be conducted in an interdisciplinary collaborative research consortium of the Department of Paediatrics, School of Medicine and Health Sciences of the University of Oldenburg, Germany (Host institution) and the Stem Cells and Neurodegeneration Research Group, School of Clinical Sciences, University of Bristol, United Kingdom (Collaborating institution).
The Stem Cells and Neuroregeneration Research Group offers access to laboratory and cell culture work facilities in Bristol.The PhD student will learn and apply the following techniques:
Culture of human neural progenitor cells and human induced pluripotent stem cells; neural organoid and assembloid differentiationHigh-content microscopy / confocal microscopyRNA analysismicroRNA seqImmunoblotting, ELISAs and immunofluorescenceFACS analysisBioinformatic strategiesIhr ProfilRequired qualifications:
University degree (Diploma (Uni) or Masters) in biology, neurobiology, molecular neuroscience or comparable fieldsGood skills in oral and written English and GermanExperience with experimental models of organ development including progenitor cell culture, desirable in the field of neuroscienceExperience in confocal microscopyPreferred qualifications:
Payment in accordance with collective bargaining law (special annual payment, public service pension scheme, asset-related benefits) incl.
30 days annual leaveSupport and guidance during your onboarding phaseA family-friendly environment with flexible working hours (flexitime) and the possibility of pro-rata mobile workBenefits from the university's health promotion programmeAn extensive and free further education programme as well as programmes geared toward the promotion of early career researchers (
/uol.de/en/school6/early-career)Unser AnspruchThere is the possibility of personal scientific qualification (doctorate).You don't know Oldenburg yet? The following link will provide you with first impressions:
moin-in-oldenburg.de.Please send your application including a CV, list of two potential referees, a brief statement of research interests and copies of certificates of academic grades to Prof.
Dr.
Axel Heep, Department of Paediatrics, University of Oldenburg, 26111 Oldenburg, Germany:
(axel.heep@uni-oldenburg.de).
Electronic applications (one pdf file) are preferred.
The application deadline is 29.10.2024.
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