PhD Position - Development of in situ Bioprinting Technologies

PhD Position - Development of in situ Bioprinting Technologies PhD Position - Development of in situ Bioprinting Technologies Articular cartilage injuries are widespread and can increase the risk of early onset osteoarthritis.
The fields of tissue engineering and bioprinting are constantly searching for new methods to create biomimetic tissue models which better replicate the organization of native tissues.
Here bioprinting strategies have the potential to revolutionize the functionality of tissues used in regenerative medicine.
The Tissue Engineering and Biofabrication Laboratory (Prof.
Marcy Zenobi-Wong) within the Department of Health Sciences & Technolgy (D-HEST) at ETH Zürich in Zurich, Switzerland, uses bioprinting to produce tissues which address unmet clinical needs.
The laboratory has recently developed a light-based 3D printing technique, capable of creating topological cell guiding cues in large scaffolds (> centimeter scale) based on optical modulation instability effect and self-focusing effect on non-linear media (e.g., photosensitive resin).
This allows for creating efficient cell guiding microstructures including microfilaments and microchannels in 3D hydrogel constructs within seconds.
In this multi-PI consortium, an in situ printing technique will be developed to treat articular cartilage injuries.
Project background The goal of this project is to develop a light based printer which can be used directly in the operation room.
This new printer will be able to crosslink photoresins and cells directly into the patient's cartilage defect, thereby promoting regeneration of the joint.
Design, assembly and validation of in situ bioprinting system
Assessment of print fidelity
Establish and test software-hardware control of the system
Optimization of safety, reliability and accuracy of the printer
Integration of multiple printheads to increase functionality of printer
Training and maintence of printer for consortium partners
Profile You have a diploma/M.Sc.
degree in mechanical engineering or biomedical engineering with strong motivation to develop the hardware and software behind the next generation of 3D bioprinters.
The following skills are sought:

3D printing:
Familiarity with light based and extrusion 3D printers, as well as characterization of 3D printing materials
Physics and Optics:
Understanding of optics, lasers, diffraction, fiberoptics
Hardware Design and Mechatronics:
Understanding of communication between devices and communication protocols
Programming:
Proficiency in python and understanding of basic software engineering
Good knowledge of Linux operating system, especially in combination with Raspberry Pi operation and Arduino
Motivation to work in a multidisciplinary and multicultural environment
This project is embedded within a large European consortium, therefore excellent written and oral communciation are essential
We offer An open and collaborative research environment
Access to and training in cutting-edge methodologies and instrumentation
Possibilities to develop entrepreneural skills and training
In line with our values , ETH Zurich encourages an inclusive culture.
We promote equality of opportunity, value diversity and nurture a working and learning environment in which the rights and dignity of all our staff and students are respected.
Visit our Equal Opportunities and Diversity website to find out how we ensure a fair and open environment that allows everyone to grow and flourish.
Curious? So are we.
We look forward to receiving your online application with the following documents:

A motivation letter describing how your background fits the profile, your scientific interests and scientific achievements to date (max.
2 pages)
CV and Transcripts from MSc and BS degrees
Contact information of 3 references
The position is available from January 1, 2025.
Please note that we exclusively accept applications submitted through our online application portal.
Applications via email or postal services will not be considered.
Further information about our laboratory can be found on our website .
Questions regarding the position should be directed to Prof.
Marcy Zenobi-Wong, Tel *** or email *** (no applications).
ETH Zurich is one of the world's leading universities specialising inscience and technology.
We are renowned for our excellent education,cutting-edge fundamental research and direct transfer of new knowledgeinto society.
Over 30,000 people from more than 120 countries find ouruniversity to be a place that promotes independent thinking and anenvironment that inspires excellence.
Located in the heart of Europe,yet forging connections all over the world, we work together todevelop solutions for the global challenges of today and tomorrow.
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