Center of Excellence Postdoc: Immunogenicity Mitigation and Immunopeptidomics

Center of Excellence Postdoc: Immunogenicity Mitigation and Immunopeptidomics

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Remote Type: On Site

Location: Canada - Burnaby

Time Type: Full time

Posted On: Posted Yesterday

Job Requisition ID: R-192064

Career Category

Research

HOW MIGHT YOU DEFY IMAGINATION?

You've worked hard to become the professional you are today and are now ready to take the next step in your career. How will you put your skills, experience and passion to work toward your goals? At Amgen, our shared mission-to serve patients-drives all that we do. It is key to our becoming one of the world's leading biotechnology companies, reaching over 10 million patients worldwide. Come do your best work alongside other innovative, driven professionals in this meaningful role.

Center of Excellence Postdoctoral Fellow - Immunogenicity Mitigation and Immunopeptidomics

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What you will do

Let's do this. Let's change the world. We are seeking a postdoctoral fellow with previous training in immunology and biochemistry to help develop the next generation of screening tools to identify and quantify the presence of immunogenic sequences, motifs, and structures in candidate therapeutic molecules by leveraging multiple different emerging technology streams. These platforms would then be used to aid in the development of biologic therapies by facilitating the selection or design of therapeutic candidates with reduced immunogenic liabilities. In this vital role you will develop, assess, and integrate new technologies to identify T and B cell epitopes in therapeutic proteins of interest.

• Lead an effort to develop and implement new B and T cell epitope determination tools and screening platforms.
• Perform various immune assays utilizing primary human cells to validate experimental data.
• Critically analyze and interpret data.
• Explore opportunities to develop and/or deploy relevant machine learning models.
• Prospect the research space to identify additional emerging technologies.
• The postdoctoral fellow will receive personalized training in relevant areas of immunology, biochemistry or peptidomics as required.

Win

What we expect of you

We are all different, yet we all use our unique contributions to serve patients. The professional we seek is a creative problem solver with these qualifications.

Basic Qualifications:

• Doctorate degree in immunology or related field.
• Deep understanding of mechanistic immunology, with previous research in the field of antigen processing/presentation or immunopeptidomics.
• A strong grasp of protein biochemistry.
• A strong background in modern molecular biology techniques.
• Excellent communicator able to write and speak about technical concepts to business, technical, and lay audiences.

Preferred Qualifications:

• Previous experience in sample preparation for mass spectrometry-based proteomics.
• Experience with standard immunology assays and immunophenotyping.
• Understanding of T and B cell biology and de novo immune response mechanisms.
• A mechanistic understanding of class II antigen processing and presentation.
• Previous experience modelling T cell responses in vitro.
• Previous experience working with primary human immune cells.

Thrive

What you can expect of us

As we work to develop treatments that take care of others, we also work to care for our teammates' professional and personal growth and well-being.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

Amgen offers a Total Rewards Plan comprising health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities including:

• Comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts.
• A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan.
• Stock-based long-term incentives.
• Award-winning time-off plans and bi-annual company-wide shutdowns.
• Flexible work models, including remote work arrangements, where possible.

Apply now

For a career that defies imagination

Objects in your future are closer than they appear. Join us.

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Application Deadline

Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.

Amgen is an Equal Opportunity employer and will consider you without regard to your race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.

About Us

Amgen is committed to unlocking the potential of biology for patients suffering from serious illnesses by discovering, developing, manufacturing and delivering innovative human therapeutics. This approach begins by using tools like advanced human genetics to unravel the complexities of disease and understand the fundamentals of human biology.

Amgen focuses on areas of high unmet medical need and leverages its biologics manufacturing expertise to strive for solutions that improve health outcomes and dramatically improve people's lives. A biotechnology pioneer since 1980, Amgen has grown to be one of the world's leading independent biotechnology companies, has reached millions of patients around the world and is developing a pipeline of medicines with breakaway potential.