• Card 29 / 34: 8 yr old MC DSH cat presented for weight loss with anorexia and vomitting PE : Temp 103 (increased) , Resp: 60 (increased) HR normal Tacky mucous membranes Weight: obese 6.1 kg Integ: 10% dehydrated; Harsh lung sounds throughout all lung field but no murmurs. The cat is laterally recumbent and somewhat responsive. CBC shows inflammatory leukogram. Biochem panel reveals Azotemia (increased BUN and Creat) , hyperglycemia Glu: 470 (normal140) Low HCO3 :10 (normal 24) , low Cl :110 (normal 125), and low Na : 144 (normal 147) with High K. Urinalysis shows Ketones 4+ and glucose 4+ Thoracic Radiographs: Diffuse, mixed interstitial and alveolar pattern suggestive of bronchopneumonia. You diagnose the cat with Diabetes Mellitus with ketoacidosis (DKA). After initial treatment (IV fluids etc..) what do you think is a good insulin therapy to send the cat home with?
    A) Regular (short acting) insulin twice daily
    B) PZI (long acting) insulin 3 times daily
    C) Regular ( short acting ) insulin 3 times daily
    D) NPH (intermediate) insulin twice daily
    E) Insulin glargine once daily

    Answer:
    D) NPH (intermediate) insulin twice daily

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Explanation:

You can also use longer-acting insulins, like PZI and glargine, but these should also be started twice daily because they often only have a duration of about 12 hours in the cat. Regular insulin is a short-acting insulin that should not be given outside the realm of DKA.

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Dr Dowers Endocrinology

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