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- How do tetanus toxin and botulinum
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Card 22 / 30: How do tetanus toxin and botulinum toxin interfere with synaptic transmission (explain in molecular detail)? How does one produce a rigid paralysis, while the other causes flaccid paralysis?
Answer:
Toxin’s heavy and light chain required to enter cell. Light chain then freed and acts as metalloprotease to enzymatically cleave different proteins of the SNARE complex (required for synaptic vesicle fusion). Tetanus tends to hit inhibitory synapses (thus rigid, due to disinhibition of motoneuron), and botulinum toxin hits NMJs and others. (Tropism of toxin.)
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Attribution:
Corey, David. HST.131 Introduction to Neuroscience, Fall 2005. (MIT OpenCourseWare: Massachusetts Institute of Technology), http://ocw.mit.edu/courses/health-sciences-and-technology/hst-131-introduction-to-neuroscience-fall-2005 (Accessed 12 Apr, 2014). License: Creative Commons BY-NC-SA
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