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Card 13 / 19:
Rb is a negative regulator that blocks the cell cycle at the G 1 checkpoint until the cell achieves a requisite size. What molecular mechanism does Rb employ to halt the cell cycle?
Rb is active when it is dephosphorylated. In this state, Rb binds to E2F, which is a transcription factor required for the transcription and eventual translation of molecules required for the G 1 /S transition. E2F cannot transcribe certain genes when it is bound to Rb. As the cell increases in size, Rb becomes phosphorylated, inactivated, and releases E2F. E2F can then promote the transcription of the genes it controls, and the transition proteins will be produced.
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