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Card 7 / 9:
How does the development of the clavicle differ from the development of other appendicular skeleton bones?
Unlike other bones of the appendicular skeleton, the clavicle develops by the process of intramembranous ossification. In this process, embryonic mesenchyme accumulates at the site of the future bone and then differentiates directly into bone-producing tissue. Because of this direct and early production of bone, the clavicle is the first bone of the skeleton to begin to ossify. However, the growth and enlargement of the clavicle continues throughout childhood and adolescence, and thus, it is not fully ossified until 25 years of age.
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